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Book synopsis

High-throughput sequencing has revolutionised the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. The topics covered range from the foundations of biological sequence analysis (alignments and hidden Markov models), to classical index structures (k-mer indexes, suffix arrays and suffix trees), Burrows–Wheeler indexes, graph algorithms and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualisations, exercises and problems, each chosen to reflect the steps of large-scale sequencing projects, including read alignment, variant calling, haplotyping, fragment assembly, alignment-free genome comparison, transcript prediction and analysis of metagenomic samples. Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing.

Book details

Book category Książki po angielsku Mathematics & science Biology, life sciences Life sciences: general issues

• Full title: Genome-Scale Algorithm Design
• Subtitle: Biological Sequence Analysis in the Era of High-Throughput Sequencing
• Author: Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu
• Language: English
• Binding: Hardback
• Number of pages: 413
• EAN: 9781107078536
• ISBN: 1107078539
• ID: 09147461
• Publisher: Cambridge University Press
• Weight: 954 g
• Dimensions: 255 × 182 × 23 mm
• Date of publishing: 07. May 2015

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