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Więcej informacji o In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity

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Opis

Over expression of 11_-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11_-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11_-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11_-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 _-HSD 1 analog of corosolic acid without nephrotoxicity.

Szczegóły książki

• Pełny tytuł: In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity
• Autor: Rakesh Jagtap, Harun Patel, Kiran Dhangar
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 56
• EAN: 9783659790010
• ISBN: 365979001X
• ID: 02852554
• Wydawca: Lambert Academic Publishing
• Waga: 95 g
• Wymiary: 229 × 152 × 3 mm
• Data wydania: 20. October 2015

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