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More about Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

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Book synopsis

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. Key Features * Summarizes current state of amiloride-sensitive sodium channel field * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal regulation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * Provides ideas on sodium channels and disease

Book details

Book category Books in English Mathematics & science Physics Applied physics

• Full title: Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
• Author: Douglas M. Fambrough, Dale J. Benos
• Language: English
• Binding: Paperback
• Number of pages: 384
• EAN: 9780120890309
• ISBN: 0120890305
• ID: 04492843
• Publisher: Elsevier Science Publishing Co Inc
• Weight: 686 g
• Dimensions: 154 × 229 × 27 mm
• Date of publishing: 22. October 1999

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