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Book synopsis

since a growth factor for Mycobacterium paratuberculosis was produced by Mycobacterium tuberculosis and seemed highly specific for the mycobacteria, its structure, if known, should provide a highly suitable model for the synthesis of compounds having a specific action against the mycobacteria ..... Francis, J (1945) in Bacteriol Rev, 1970, 34, 99-125 by Snow, GA Small molecule heterocyclic compounds that mimics hydroxyphenyl oxazoline portion of mycobactin were designed to interfere mycobactin biosynthesis. Mycobactin is a mycobacterial "siderophore" responsible for iron acquisition from host cell. Iron and mycobactin are two important virulence factors and restricting the iron acquisition by blocking the mycobactin biosynthesis will in turn affect the growth of mycobacteria inside the host cell. A library of around thirty-nine molecules were synthesized and tested for their anti-tubercular activity under iron rich and deprived media.

Book details

• Full title: Anti-tubercular Drug Design Exploring Mycobactin Biosynthetic Pathway
• Subtitle: Designing molecules that mimics hydroxyphenyl oxazoline portion of mycobactin
• Author: Venkatesan Jayaprakash, Barij Nayan Sinha
• Language: English
• Binding: Paperback
• Number of pages: 72
• EAN: 9783659439957
• ID: 02201493
• Publisher: LAP Lambert Academic Publishing
• Weight: 125 g
• Dimensions: 220 × 150 × 4 mm
• Date of publishing: 23. October 2013

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