Code: 01653570

Biosynthesis

Name: Biosynthesis
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 01653570
Price: 307.97 EUR
Availability: InStock
Author: Finian J. Leeper
ISBN: 9783642085833

by Finian J. Leeper, John C. Vederas, R. Croteau, E.M. Davis

Language: English
Binding: Paperback
Number of pages: 247
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 2010
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Book synopsis

This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). Volume 1 covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.