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Book synopsis

A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.

Book details

Book category Books in English Medicine Clinical & internal medicine Diseases & disorders

• Full title: Myeloid Leukemia
• Subtitle: Methods and Protocols
• Author: Harry Iland, Mark Hertzberg, Paula Marlton
• Language: English
• Binding: Hardback
• Number of pages: 320
• EAN: 9781588294852
• ISBN: 1588294854
• ID: 03615948
• Publisher: Humana Press Inc.
• Weight: 663 g
• Dimensions: 235 × 155 × 27 mm
• Date of publishing: 15. November 2005

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