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Book synopsis

Tissue engineering has been redefined as the use of §physical, chemical, biological and engineering §processes to control and direct the aggregate §behaviors of cells .This offers tremendous §opportunities for designing in vitro physiological §models to study disease pathogenesis, inventing §cell-based therapeutics in clinical applications and §developing novel pharmaceutical methods for reducing §the use of animals in drug testing. However, while §using biomanufacturing processes, cells are §subjected to an array of mechanical forces which may §injure it. While experimental studies have been §conducted for specific bio-fabrication systems to §understand cell responses, an engineering model is §also needed that can be used to predict the effect §of mechanical forces on cells. A multi scale §modeling approach for the analysis of cell damage in §bioprinted tissue constructs is presented here. The §approach includes analysis of the tissue constructs §at a macro scale model, developing a multi-cellular §scale model and a single cell model wherein the §microstructures of the cell like the nucleus and the §cytoplasm have been incorporated.

Book details

Book category Books in English Technology, engineering, agriculture Mechanical engineering & materials Mechanical engineering

• Full title: Multi-Scale Computational Modeling of Bioprinted Tissue Constructs
• Author: Kalyani Nair
• Language: English
• Binding: Paperback
• Number of pages: 156
• EAN: 9783639099072
• ISBN: 3639099079
• ID: 06818927
• Publisher: VDM Verlag
• Weight: 218 g
• Dimensions: 229 × 152 × 8 mm
• Date of publishing: 02. December 2008

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