Code: 12828738

New Algorithms for Single Particle Cryo Electron Microscopic Image Processing

Name: New Algorithms for Single Particle Cryo Electron Microscopic Image Processing
Brand: Cuvillier Verlag
SKU: 12828738
Price: 39.53 EUR
Availability: InStock

by Jan-Martin Kirves

Language: English
Binding: Paperback
Number of pages: 174
Publisher: Cuvillier Verlag, 2015
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Book synopsis

In this thesis four approaches to increase the quality and assure the validity of three-dimensional (3D) models generated within the single particle cryo-electron microscopy (CryoEM) workflow are introduced. ProteoPlex is a high-throughput technique and software tool for the evaluation of the most stabilizing biochemical conditions of macromolecular complexes. The validation technique 3D correlation of tilted pairs (3DCTP) can be applied alongside the single particle refinement cycle to detect model bias utilizing tilted pair images. A new analysis method identifies the presence of overfitting in high resolution CryoEM 3D structures. Finally, a set of criteria covering different model quality aspects of the generated 3D structure is introduced.

Book details

39.53 €

Full title: New Algorithms for Single Particle Cryo Electron Microscopic Image Processing
Author: Jan-Martin Kirves
Language: English
Binding: Paperback
Number of pages: 174
EAN: 9783954049073
ISBN: 3954049074
ID: 12828738
Publisher: Cuvillier Verlag
Weight: 234 g
Dimensions: 210 × 148 × 9 mm
Date of publishing: 06. January 2015