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Book synopsis

A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.

Book details

Book category Books in English Medicine Other branches of medicine Pharmacology

• Full title: Peptidomimetics Protocols
• Author: Wieslaw M. Kazmierski
• Language: English
• Binding: Hardback
• Number of pages: 549
• EAN: 9780896035171
• ISBN: 0896035174
• ID: 01400753
• Publisher: Humana Press Inc.
• Weight: 2260 g
• Dimensions: 235 × 155 × 36 mm
• Date of publishing: 19. October 1998

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