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Book synopsis

As a starting point the authors address the fundamental question "What underlying forces are responsible for the observed patterns of variability, given a collection of DNA sequences?" In approaching this question they introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. They then discuss the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from "neutral evolution."

Book details

Book category Books in English Mathematics & science Biology, life sciences Life sciences: general issues

• Full title: Probability Models for DNA Sequence Evolution
• Author: Richard Durrett
• Language: English
• Binding: Hardback
• Number of pages: 431
• EAN: 9780387781686
• ISBN: 0387781684
• ID: 01247776
• Publisher: Springer-Verlag New York Inc.
• Weight: 614 g
• Dimensions: 244 × 164 × 30 mm
• Date of publishing: 12. August 2008

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