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Book synopsis

A unique overview that melds the concepts of conditional probability and stochastic processes into real-life applications The role of randomization techniques in clinical trials has become increasingly important. This comprehensive guide combines both the applied aspects of randomization in clinical trials with a probabilistic treatment of properties of randomization. Taking an unabashedly non-Bayesian and nonparametric approach to inference, the book focuses on the linear rank test under a randomization model, with added discussion on likelihood-based inference as it relates to sufficiency and ancillarity. Developments in stochastic processes and applied probability are also given where appropriate. Intuition is stressed over mathematics, but not without a clear development of the latter in the context of the former. Providing a consolidated review of the field, the book includes relevant and practical discussions of: The benefits of randomization in terms of reduction of bias Randomization as a basis for inference Covariate-adaptive and response-adaptive randomization Current philosophies, controversies, and new developments With ample problem sets, theoretical exercises, and short computer simulations using SAS, Randomization in Clinical Trials: Theory and Practice is equally useful as a standard textbook in biostatistics graduate programs as well as a reliable reference for biostatisticians in practice.

Book details

Book category Books in English Medicine Medicine: general issues Medical equipment & techniques

• Full title: Randomization in Clinical Trials
• Subtitle: Theory and Practice
• Author: William F. Rosenberger, John M. Lachin
• Language: English
• Binding: Hardback
• Number of pages: 288
• EAN: 9780471236269
• ISBN: 0471236268
• ID: 04888843
• Publisher: John Wiley & Sons Inc
• Weight: 572 g
• Dimensions: 243 × 168 × 22 mm
• Date of publishing: 30. July 2002

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