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Book synopsis

This books deals with a catalytic platform for the enzymatic synthesis of tertiary alcohols. A certain class of hydrolases bearing the GGG(A)X-motif are efficient and highly selective catalysts for this difficult reaction. The number of available biocatalysts could be extended by making use of a structure-guided screening in metagenome-derived enzyme libraries. Two highly selective enzymes were identified. One model enzyme, esterase BS2, was optimized and the hydrolysis of tertiary esters was studied in detail. In a protein design study, novel enzyme variants were generated by semi-rational protein design methods, which led to the identification of mutants with strongly increased or even inverse enantioselectivity. The application of the platform to the kinetic resolution of a building block of pharmaceutical interest is described.

Book details

• Full title: Studies on the enzymatic synthesis of optically pure tertiary alcohols
• Subtitle: Biocatalysis and Protein Design
• Author: Robert Kourist
• Language: English
• Binding: Paperback
• Number of pages: 76
• EAN: 9783639193510
• ID: 06827443
• Publisher: VDM Verlag Dr. Müller
• Dimensions: 220 × 150 × 5 mm
• Published: 2009

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