You might also like

More about Chemistry of -Lactams

• Book details
• Synopsis
• Trending among others

You get 154 loyalty points

Book synopsis

It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r) o '" (I) 'C0 H 2 Penicillin was the first naturally occurring antibiotic to be characterised and used in clinical medicine. It is now seen as the progenitor of the tJ-Iactam family of antibiotics, which are characterised by the possession of the four membered tJ-Iactam ring. Chapters in this book will describe how current research has demonstrated that other lactam structures may also show antibacterial activity. Penicillins and cephalosporins (2), the second member of the tJ-Iactam antibiotic family, were both originally discovered in fungi but later detected in streptomycetes. Until 1970 penicillins and cephalosporins were the only examples of naturally occurring tJ-Iactam antibiotics. The discovery of 7-a-methoxy cephalosporins (3) from Streptomyces in 1971 stimulated the search for novel tJ-Iactam antibiotics from microbes, both by using sensitive new screening procedures, and by laboratory synthesis.

Book details

Book category Books in English Mathematics & science Chemistry Organic chemistry

• Full title: Chemistry of -Lactams
• Author: M. I. Page
• Language: English
• Binding: Paperback
• Number of pages: 351
• EAN: 9789401053006
• ISBN: 9401053006
• ID: 07122998
• Publisher: Springer
• Weight: 575 g
• Dimensions: 235 × 155 × 21 mm
• Date of publishing: 29. October 2012

Trending among others

---

---

---