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Book synopsis

As an important chain-breaking antioxidant, the role of Vitamin E has attracted attentions from all over the world. Alpha-Tocopherol and gamma-tocopherol are two of the eight different forms of vitamin E. The dietary intake of gamma-tocopherol is generally higher than that of alpha-tocopherol. However, the levels of alpha-tocopherol in human blood have consistently been shown to be higher than those of gamma-tocopherol. This could be due, in part, to a differential cellular uptake of the two tocopherol forms. We sought to resolve this question by studying the uptake and depletion of both alpha-tocopherol and gamma-tocopherol in RAW 264.7 macrophages. The results indicate that a faster uptake and depletion of gamma-tocopherol compared with alpha-tocopherol. The presence of gamma-tocopherol can promote the uptake of alpha-tocopherol by macrophages. The metabolism of alpha-tocopherol was faster than gamma-tocopherol. These results implied the existence of a hypothetical transport protein, which can preferentially select gamma-tocopherol over alpha-tocopherol. The affinity of this transport protein for alpha-tocopherol could be increased by the presence of gamma-tocopherol.

Book details

• Full title: THE UPTAKE AND DEPLETION OF TOCOPHEROLS
• Subtitle: THE UPTAKE AND DEPLETION OF TOCOPHEROLS IN RAW 264.7 MACROPHAGES
• Author: Rong Gao
• Language: English
• Binding: Paperback
• Number of pages: 76
• EAN: 9783843374125
• ID: 06943978
• Publisher: LAP Lambert Academic Publishing
• Weight: 131 g
• Dimensions: 220 × 150 × 5 mm
• Published: 2010

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