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Book synopsis

In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose than a conventional DNA vaccine. DNA replicon doses as low as 10 ng significantly prevented from IgE induction by subcutaneous protein sensitization. Furthermore, in a therapeutic approach with the same construct, DNA replicons balanced an ongoing allergic response. These data were confirmed with a DNA replicon encoding the clinically relevant timothy grass pollen allergen Phl p 5. In addition, lung pathology could be prevented by pre-vaccination with DNA replicons as measured by the magnitude of eosinophilia, goblet cell hyperplasia, IL-5 production and proliferation of endothelial cells.

Book details

Book category Books in English Medicine Pre-clinical medicine: basic sciences Medical genetics

• Full title: DNA Replicons - Next-generation Vaccines against Allergy
• Author: Maximilian Gabler
• Language: English
• Binding: Paperback
• Number of pages: 132
• EAN: 9783836495554
• ISBN: 3836495554
• ID: 06943333
• Publisher: VDM Verlag Dr. Mueller E.K.
• Weight: 186 g
• Dimensions: 229 × 152 × 7 mm
• Date of publishing: 08. April 2008

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