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Więcej informacji o Bioisosteres in Medicinal Chemistry

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Opis

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.§As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.§The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,§while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part§covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of§protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.§With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Szczegóły książki

Kategoria Książki po angielsku Technology, engineering, agriculture Industrial chemistry & manufacturing technologies Industrial chemistry

• Pełny tytuł: Bioisosteres in Medicinal Chemistry
• Autor: Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 256
• EAN: 9783527330157
• ISBN: 3527330151
• ID: 01551080
• Wydawca: Wiley-VCH Verlag GmbH
• Waga: 632 g
• Wymiary: 248 × 173 × 16 mm
• Data wydania: 22. August 2012

Ulubione w innej kategorii

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