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Viac informácií o knihe Alcohol Abstinence in Vulnerable Subpopulations of Drinkers

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Alcohol dependence is a debilitating disorder for the§individual and very costly for society. Because§alcoholism is such a complex disease, animal models§are used to mimic components of the disease.§Alcoholism is defined by cycles of intoxication and§abstinence, resulting in the compulsion to drink§alcohol, loss of control in limiting intake, and§emergence of negative emotional states. These studies§focused on behaviors during protracted abstinence in§rats genetically and environmentally susceptible to§alcohol dependence. Specifically, rats selectively§bred for high alcohol preference were tested for§anxiety-like behaviors, and genetically heterogeneous§rats were made dependent on alcohol and tested for§relapse behavior. Neuropeptide Y§(NPY), an endogenous anxiolytic, was tested for its§effects on these behaviors. Anxiety-like behavior was§suppressed by NPY regardless of alcohol exposure§history. However, NPY suppressed alcohol§drinking only in rats that underwent cycles of§abstinence. These results suggest that dysregulation§of brain NPY systems is an important motivational§factor that drives alcohol consumption in vulnerable§subpopulations of drinkers.

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Zaradenie knihy Knihy po anglicky Mathematics & science Biology, life sciences

• Celý názov: Alcohol Abstinence in Vulnerable Subpopulations of Drinkers
• Podnázov: A Role for Neuropeptide Y
• Autor: Nicholas Gilpin
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 172
• EAN: 9783639121919
• ISBN: 3639121910
• ID: 06820999
• Nakladateľ: VDM Verlag
• Hmotnosť: 259 g
• Rozmery: 229 × 152 × 10 mm
• Dátum vydania: 20. March 2009

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