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This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.

Parametre knihy

Zaradenie knihy Knihy po anglicky Medicine Other branches of medicine Pharmacology

• Celý názov: Alternatives for Dermal Toxicity Testing
• Autor: Chantra Eskes, Erwin van Vliet, Howard I. Maibach
• Jazyk: Angličtina
• Väzba: Pevná
• Počet strán: 592
• EAN: 9783319503516
• ISBN: 3319503510
• ID: 15362950
• Nakladateľ: Springer International Publishing AG
• Hmotnosť: 986 g
• Rozmery: 235 × 155 × 29 mm
• Dátum vydania: 16. August 2017

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