Mohlo by sa vám tiež páčiť

Viac informácií o knihe Immunotoxin for the Depletion of Autoreactive B Cells in MS

• Parametre knihy
• Anotácia kniha
• Obľúbené z iného súdka

Nákupom získate 154 bodov

Anotácia knihy

The aim of the presented work was the design, production, and characterisation of a novel immunotoxin in the context of MS. Proteins were expressed in a prokaryotic and eukaryotic system, respectively. Stable producing 293T cell populations were established for the reference protein PLP that showed a good expression yield and a high purity after purification was obtained. This is the first time that a functional PLP fusion protein was expressed in 293T cells and purified from cell supernatant. The characterisation of the immunotoxin PLP-ETA comprised the verification of the functionality of the expressed protein in the context of the binding specifity and toxicity on a PLP- specific hybridoma cell line. This hybridoma cell line that served as a very feasible in vitro B cell model is the first step in the determination of the functionality of an immunotoxin. Documenting a high binding specifity and specific toxicity of this novel PLP based immunotoxin on a PLP- reactive hybridoma cell line, this work provides a contribution to the B cell specific therapies with immunotoxins in MS.

Parametre knihy

Zaradenie knihy Knihy po anglicky Mathematics & science Biology, life sciences

• Celý názov: Immunotoxin for the Depletion of Autoreactive B Cells in MS
• Autor: Sigrun Klandt
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 80
• EAN: 9783639282535
• ISBN: 3639282531
• ID: 06835428
• Nakladateľ: VDM Verlag
• Hmotnosť: 127 g
• Rozmery: 229 × 152 × 5 mm
• Dátum vydania: 18. August 2010

Obľúbené z iného súdka

---

---

---