Mohlo by sa vám tiež páčiť

Viac informácií o knihe Contributions to the Total Synthesis of Branimycin

• Parametre knihy
• Anotácia kniha
• Obľúbené z iného súdka

Nákupom získate 301 bodov

Anotácia knihy

The classical drugs used for the treatment of common bacterial diseases are often characterised by serious side effects and high-toxicity profiles. Additionally, in the last decade a rapid development of multidrug-resistant strains of bacterial pathogens has been observed. Consequently, there is an urgent need to discover new structural classes of antibacterial compounds, and to develop agents which are able to replace (or be associated with) the drugs which are currently in use. In 1998 researchers at the University of Göttingen isolated from a stem of Streptomyces a novel antibiotic, named branimycin. To access the complex structure of branimycin by total synthesis, the molecule was divided retrosynthetically into two fragments. Herein, 3 approaches are outlined to access the cis-octalin core fragment through substrate-controlled intramolecular (IMDA) or transannular (TADA) Diels-Alder reactions. Furthermore, the construction of the side-chain fragment in a convergent manner by the reaction of a differentially protected glyceraldehyde derivative with a chiral allenyl silane is described.

Parametre knihy

Zaradenie knihy Knihy po anglicky Mathematics & science Chemistry Organic chemistry

• Celý názov: Contributions to the Total Synthesis of Branimycin
• Autor: Felzmann Wolfgang
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 288
• EAN: 9783838150994
• ISBN: 3838150996
• ID: 02863253
• Nakladateľ: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Hmotnosť: 426 g
• Rozmery: 229 × 152 × 18 mm
• Dátum vydania: 02. November 2015

Obľúbené z iného súdka

---

---

---