Mohlo by sa vám tiež páčiť

Viac informácií o knihe Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR

• Parametre knihy
• Anotácia kniha
• Obľúbené z iného súdka

Nákupom získate 188 bodov

Anotácia knihy

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Parametre knihy

Zaradenie knihy Knihy po anglicky Mathematics & science Chemistry Organic chemistry

• Celý názov: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR
• Autor: Guangtao Zhang
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 160
• EAN: 9783639309690
• ISBN: 3639309693
• ID: 06837893
• Nakladateľ: VDM Verlag
• Hmotnosť: 245 g
• Rozmery: 229 × 152 × 9 mm
• Dátum vydania: 03. February 2011

Obľúbené z iného súdka

---

---

---