Kód: 18203195
Objective of the present study is to prepare edaravone nanoparticle by using 3 level factorial deign using design expect 9 software. The software produced 17 formulations with varying concentration of EC, PVA and Tween-80 with a f ... celý popis
Angličtina
32.10 €
Bežne: 37.70 €
Ušetríte 5.60 €

Nákupom získate 78 bodov
Anotácia knihy
Objective of the present study is to prepare edaravone nanoparticle by using 3 level factorial deign using design expect 9 software. The software produced 17 formulations with varying concentration of EC, PVA and Tween-80 with a fixed dose of edaravone (5 mg). The drug and polymer compatibility study was done by FTIR spectroscopy. All the 17 formulations morphology was spherical in shape and the zeta potential in the rage of -12.7 mV to -28.5 mV. The particle size and entrapment efficiency was the main independent variable in formula optimization. The in-vitro dissolution of all the formulations were followed initial burst release followed by sustained release more than 12 hours. Based on the factorial design studies, we optimized formulation of edaravone nanoparticle.
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32.10 €
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Osobný odber Bratislava a 12840 dalších
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