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Viac informácií o knihe Novel Therapeutic Agents for the Treatment of Prostate Cancer

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Anotácia knihy

Standard hormonal therapy with currently available §anti-androgens and LHRH analogs becomes ineffective §in the hormone-refractory stage of prostate cancer §due to the changes in androgen receptor signaling §axis in prostate cancer cells. To develop effective §therapies against hormone-refractory prostate §cancer, §novel agents targeting multiple points at the §cellular signaling cascades are needed in order to §produce the maximal therapeutic efficacy against §late §stage prostate cancer. In this dissertation work, we §have presented the design and development of novel §agents targeting three key signaling pathways §towards §their ultimate development into the effective §therapies against hormone refractory prostate §cancer. §Specifically, we have discovered and designed a §diverse array of novel molecules targeting the AR §signaling pathway, the sarco-endoplasmic reticulum §calcium ATPase pump driven calcium homeostasis and §the proteolytic activity of prostate specific §antigen §.

Parametre knihy

Zaradenie knihy Knihy po anglicky Medicine Clinical & internal medicine Diseases & disorders

• Celý názov: Novel Therapeutic Agents for the Treatment of Prostate Cancer
• Podnázov: Design and Development of Novel Anti-androgens, Thapsigargin Analogs and Inhibitors of Prostate Specific Antigen
• Autor: Pratap Singh
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 196
• EAN: 9783639090505
• ISBN: 3639090500
• ID: 06818154
• Nakladateľ: VDM Verlag Dr. Mueller E.K.
• Hmotnosť: 268 g
• Rozmery: 229 × 152 × 11 mm
• Dátum vydania: 11. November 2008

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