Code: 01399710

The Future of Predictive Safety Evaluation

Name: The Future of Predictive Safety Evaluation
Brand: Springer Netherlands
SKU: 01399710
Price: 137.20 EUR
Availability: BackOrder

by A.N. Worden, D.V. Parke, J. Marks

Language: English
Binding: Hardback
Number of pages: 320
Publisher: Springer Netherlands
More about this

137.20 €

Availability:

50/50

We think title might be available. Upon your order we will do our best to get it within 6 weeks.
We search the world

Availability alert

Add to wishlist

Saving Teyrnaseira
13.89 €
Buy

Give this book as a present today

Order book and choose Gift Order.
We will send you book gift voucher at once. You can give it out to anyone.
Book will be send to donee, nothing more to care about.

Book gift voucher sample Read more

Availability alert

We will watch availability for you

Enter your e-mail address and once book will be available,
we will send you a message. It's that simple.

More about The Future of Predictive Safety Evaluation

Book details
Synopsis
Trending among others

You get 340 loyalty points

Book synopsis

Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.