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Viac informácií o knihe Endocrine FGFs and Klothos

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Anotácia knihy

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Parametre knihy

Zaradenie knihy Knihy po anglicky Medicine Pre-clinical medicine: basic sciences Physiology

• Celý názov: Endocrine FGFs and Klothos
• Autor: Makoto Kuro-o
• Jazyk: Angličtina
• Väzba: Pevná
• Počet strán: 210
• EAN: 9781461408864
• ISBN: 1461408865
• ID: 03615728
• Nakladateľ: Springer-Verlag New York Inc.
• Hmotnosť: 635 g
• Rozmery: 254 × 178 × 18 mm
• Dátum vydania: 11. January 2012

Obľúbené z iného súdka

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