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Viac informácií o knihe Cancer Genome and Tumor Microenvironment

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Anotácia knihy

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late 80s-early 90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are soft-wired , i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

Parametre knihy

Zaradenie knihy Knihy po anglicky Medicine Clinical & internal medicine Diseases & disorders

• Celý názov: Cancer Genome and Tumor Microenvironment
• Autor: Andrei Thomas-Tikhonenko
• Jazyk: Angličtina
• Väzba: Pevná
• Počet strán: 480
• EAN: 9781441907103
• ISBN: 1441907106
• ID: 01420458
• Nakladateľ: Springer-Verlag New York Inc.
• Hmotnosť: 1022 g
• Rozmery: 235 × 155 × 36 mm
• Dátum vydania: 14. December 2009

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