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Viac informácií o knihe Cytochrome P450

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Anotácia knihy

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritative and practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.

Parametre knihy

Zaradenie knihy Knihy po nemecky Naturwissenschaften, Medizin, Informatik, Technik Medizin Pharmazie

• Celý názov: Cytochrome P450
• Autor: Gary W. Caldwell
• Jazyk: Angličtina
• Väzba: Pevná
• Počet strán: 392
• EAN: 9781071615416
• ISBN: 1071615416
• ID: 35357334
• Nakladateľ: Springer US
• Hmotnosť: 932 g
• Rozmery: 260 × 183 × 27 mm
• Dátum vydania: 10. July 2021

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