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Viac informácií o knihe MHC Class I Antigens In Malignant Cells

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Anotácia knihy

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy.§

Parametre knihy

Zaradenie knihy Knihy po anglicky Medicine Clinical & internal medicine Diseases & disorders

• Celý názov: MHC Class I Antigens In Malignant Cells
• Podnázov: Immune Escape And Response To Immunotherapy
• Autor: Maria Teresa Cabrera Castillo, Natalia Aptsiauri, Angel Miguel Garcia-Lora
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 50
• EAN: 9781461465423
• ISBN: 1461465427
• ID: 01428575
• Nakladateľ: Springer, Berlin
• Hmotnosť: 113 g
• Rozmery: 235 × 156 × 5 mm
• Dátum vydania: 18. December 2012

Obľúbené z iného súdka

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