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Book synopsis

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve drug-like characteristics in addition to efficacy properties and good safety profiles of drug candidates.§Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.§

Book details

Book category Knihy po anglicky Medicine Other branches of medicine Pharmacology

• Full title: Optimization in Drug Discovery
• Subtitle: In Vitro Methods
• Author: Gary W. Caldwell, Zhengyin Yan
• Language: English
• Binding: Hardback
• Number of pages: 597
• EAN: 9781627037419
• ISBN: 1627037411
• ID: 02067260
• Publisher: Humana Press Inc.
• Weight: 1339 g
• Dimensions: 254 × 178 × 38 mm
• Date of publishing: 09. November 2013

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