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Viac informácií o knihe Scope and Limitations of the T-Reaction

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Anotácia knihy

The quinoline motif is an integral part of a wide variety of bioactive classes of compounds.§§An increasingly popular entry into tetrahydroquinolines is represented by the T-reaction, i.e. a subtype of the transformations relying on the isomerization-cyclization sequence known as the tert.-amino-effect.§§The latter was shown to proceed via a most remarkable helical dipolar intermediate generated upon a hydrideshift from an alpha-amino-C-H in tert.-anilines to an unsaturated ortho-substituent, accomplishing C-C-bond formation from a nonactivated NCH-moiety.§§The tert.-amino-effect was first brought to the attention of the synthetic community in the seminal contribution of O. Meth-Cohn and H. Suschitzky from 1972. Since then, the protocol has progressively evolved into a convergent, economical and yield-efficient preparation of structurally diverse, highly functionalized and pharmacologically valuable heterocycles, bearing stereoselectively introduced centers of chirality.

Parametre knihy

Zaradenie knihy Knihy po anglicky Mathematics & science Chemistry

• Celý názov: Scope and Limitations of the T-Reaction
• Podnázov: The Tert.-amino-effect in the Synthesis of Chiral Heterocycles
• Autor: Constantin Rabong
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 204
• EAN: 9783639032819
• ISBN: 3639032810
• ID: 06812975
• Nakladateľ: VDM Verlag Dr. Mueller E.K.
• Hmotnosť: 304 g
• Rozmery: 229 × 152 × 11 mm
• Dátum vydania: 01. May 2008

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