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Viac informácií o knihe Studies Toward the Synthesis of Lomaiviticins and Englerins

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Anotácia knihy

Part I: Lomaiviticins A and B are novel C2-symmetric dimeric molecules with profound cytotoxic activity. The most challenging feature of these molecules is the densely functionalized central core. We envisioned the synthesis of the lomaiviticin core by an unprecedented Diels-Alder dimerization of ortho- quinols and masked ortho-benzoquinones, followed by the fragmentation of the extra carbon-carbon bond. This chapter describes the stereoselective elaboration of the ortho-quinol and masked ortho- benzoquinone dimers to the fragmentation precursors and the unsuccessful attempts to effect the scission of the extra bond. Part II: Englerin A is a new guaiane sesquiterpene and has been shown to be a selective renal cancer inhibitor. We envisioned the synthesis of englerin A via a novel strategy featuring Wagner-Meerwein rearrangement followed by intramolecular cation trapping. This chapter describes the stereoselective synthesis of the key cis-decalin intermediate from (-)-carvone and the unsuccessful attempts to realize the skeletal rearrangement.

Parametre knihy

Zaradenie knihy Knihy po anglicky Mathematics & science Chemistry Organic chemistry

• Celý názov: Studies Toward the Synthesis of Lomaiviticins and Englerins
• Podnázov: Part I: Lomaiviticins Part II: Englerins
• Autor: Srinivas Achanta
• Jazyk: Angličtina
• Väzba: Brožovaná
• Počet strán: 116
• EAN: 9783639369885
• ISBN: 3639369882
• ID: 06843737
• Nakladateľ: VDM Verlag
• Hmotnosť: 181 g
• Rozmery: 229 × 152 × 7 mm
• Dátum vydania: 15. July 2011

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